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Timeline for Testosterone Injections to Work

Submitted by Robb Bird on Fri, 03/30/2018 - 09:00

Testosterone Replacement Therapy

Testosterone therapy is not a quick fix that will end or reverse all symptoms of low testosterone overnight, but that does not mean that someone will have to wait months and months before he or she starts to notice positive improvements in their life. How quickly testosterone injections work in the body is going to be subject to how each individual’s system responds to the hormone.

The information highlighted in this article is a guideline of what to expect but is not set in stone. Some people may experience certain results at a faster pace while others may find it takes a little longer to see positive changes. How quickly testosterone therapy works for each person is also, in part, dependent on the steps taken to assist the process by making subtle changes in one’s lifestyle. Getting proper sleep, eating well, and exercising will all help improve the effectiveness of testosterone treatment.

It has been shown that most patients asking how soon testosterone injections work are anticipating tangible results they can see, whether in energy, muscle growth, reduction of stiffness and joint pains, or improved libido. The first result is not one that can be seen, but it is the most important as this is the body achieving balance with testosterone levels becoming normalized within a few days of the first injection.

Most individuals will start to notice significant changes within 4 to 6 weeks of beginning treatment with testosterone injections, but some changes may actually be felt and seen much earlier. The next section will feature a timeline of what to expect, and when – but please remember this is a generalization and each person’s results may differ.


It helps to have a visual in terms of how quickly testosterone injections start to kick in. The timeline below best illustrates when many of the benefits of treatment for low testosterone levels will begin to be noticeable in one’s life.

Within a few days of beginning testosterone injections:

  • Improved insulin sensitivity

3 weeks after treatment begins:

  • Improved sex drive, sexual thoughts, fantasy, satisfaction, and libido

  • Increase in morning erections in men

  • Reduced anxiety, aggression, and improved sociability

  • Better perceived quality of life

  • Reduced inflammation in the body between 3 and 12 weeks

4 weeks after the start of testosterone injections:

  • Improved lipid profile – decrease in triglycerides and total cholesterol

  • Increase in full erections and sexual performance in men and women

6 weeks after beginning treatment for low testosterone:

  • Improved mood

  • Decreased depression symptoms

3 months (12 weeks) from the start of testosterone treatment:

  • Better glycemic control (3 – 12 months)

  • Improved erythropoiesis – formation of red blood cells

  • Decline in blood pressure (3 – 9 months)

  • Increased exercise capacity is shown in men with chronic heart failure

  • Decrease in LDL cholesterol and increase in HDL cholesterol (3 – 12 months)

  • Noticeable change in lean body mass, fat mass, and muscle strength by months 3 through 4

6 months into treatment with testosterone:

  • Increased bone density

  • Possible rise in PSA levels in men

12-month benefits:

  • Possible prostate-specific antigen and volume rise

Middle Aged Man doing push-ups


By the end of the first year of treatment for low testosterone, here is what to expect from testosterone injections:

  • Peak effects of erythropoiesis – red blood cell formation

  • Improved glycemic control

  • Stabilized muscle strengthening

  • Stronger bones

  • Brighter, happier mood and outlook

  • Better sex

  • Improved lean body mass – reduced fat

  • Deeper sleep

  • Sharper brain functions

  • Plateauing of prostate-specific antigen and volume

  • Improved appearance

  • Lower blood pressure, cholesterol, and triglyceride levels

  • Increased exercise capacity

The results of testosterone injections can be truly life-changing for someone who experienced debilitating symptoms associated with low testosterone.


Testosterone pills are rarely recommended for two reasons:

  1. Testosterone pills go to the stomach, where the digestive enzymes begin to tear apart the medicinal properties of testosterone.

  2. The balance of testosterone pills winds up in the liver, where toxicity can build up and cause health problems.

For these reasons, it isn’t a treatment we recommend.


We know that most are eager to see and feel positive changes, which is why the question – when will I see results from testosterone – is the most frequently asked.

Those patients who choose not to use injections tend to opt for testosterone gel or cream. The timeline for the gel/cream to work is roughly the same as with the testosterone cypionate results timeline. The benefits may come a bit slower because (unlike testosterone injections where the entire dosage is readily absorbed into the bloodstream) there is no way of knowing exactly how much testosterone is absorbed through the skin.

The initial benefits of improved sex drive, better perception of quality of life, and reduced anxiety will most likely still occur during the first month – just perhaps not to the same degree. Some men and women do feel effects of testosterone quicker with the gel or cream. There is no way of knowing until the treatment is started. Each person’s body processes the various forms of testosterone in a unique way.

To receive further information about how quickly testosterone therapy works, what you can expect from treatment, how to get tested for low testosterone, and what the best type of testosterone for your needs will be, contact us. We offer confidential consultations at no charge to men and women. Call today to learn about our affordable hormone replacement options.